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Test Code OLIGS Oligoclonal Banding, Serum


Specimen Required


Only orderable as part of a profile. For more information see:

-OLIG / Oligoclonal Banding, Serum and Spinal Fluid

-MSP3 / Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid

 

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Diagnosis of multiple sclerosis; especially useful in patients with equivocal clinical presentation and radiological findings

 

Determining number of serum oligoclonal bands in order to calculate the number of cerebrospinal fluid-specific bands present

Method Name

Only orderable as part of a profile. For more information see:

-OLIG / Oligoclonal Banding, Serum and Spinal Fluid

-MSP3 / Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid

 

Isoelectric Focusing (IEF) with IgG Immunoblot Detection

Reporting Name

Serum Bands

Specimen Type

Serum

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reject Due To

Gross hemolysis OK
Gross lipemia Reject
Gross icterus    OK

Clinical Information

The diagnosis of multiple sclerosis (MS) is dependent on clinical, radiological, and laboratory findings. The detection of increased intrathecal immunoglobulin (Ig) synthesis is the basis for current diagnostic laboratory tests for MS. These tests include kappa free light chains in the cerebrospinal fluid (CSF) and CSF oligoclonal band (OCB) detection. Abnormal CSF OCB patterns have been reported in 70% to 80% of MS patients.

 

Increased intrathecal Ig synthesis may occur in other inflammatory CSF diseases, and therefore, this assay is not specific for MS

Reference Values

Only orderable as part of a profile. For more information see:

-OLIG / Oligoclonal Banding, Serum and Spinal Fluid

-MSP3 / Multiple Sclerosis (MS) Profile, Serum and Spinal Fluid

Day(s) Performed

Monday through Friday

Report Available

4 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83916

Specimen Minimum Volume

0.4 mL