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Test Code METSP MET (SP44), Semi-Quantitative Immunohistochemistry, Manual


Shipping Instructions


Attach the green "Attention Pathology" address label (T498) to the outside of the transport container before putting into the courier mailer.



Necessary Information


A pathology/diagnostic report and a brief history are required.



Specimen Required


Specimen Type: Tissue

Supplies: Pathology Packaging Kit (T554)

Submit:

Formalin-fixed, paraffin-embedded tissue block

OR

3 Unstained glass, "positively charged" slides with 4-microns formalin-fixed, paraffin-embedded tissue

Collection Instructions: Store slides at 2 to 8° C and send within 45 days.

Additional Information: One slide will be stained with hematoxylin and eosin and returned.


Useful For

Aiding in the identification of normal and neoplastic MET expressing cells

Method Name

Immunohistochemistry (IHC)

Reporting Name

MET (SP44), SemiQuant IHC, Manual

Specimen Type

Special

Specimen Stability Information

Specimen Type Temperature Time
Special Ambient (preferred)
  Refrigerated 

Reject Due To

Decalcified paraffin embedded tissue Reject
Wet/frozen tissue Reject
Cytology smears Reject
Noncharged slides Reject
ProbeOn slides Reject
Snowcoat slides Reject
Nonformalin fixed tissue, including CytoLyt, SurePath, alcohol-formalin-acetic acid (AFA), 95% ethanol, PREFER and zinc formalin fixatives Reject
Nonparaffin embedded tissue Reject

Clinical Information

MET is a cell surface receptor tyrosine kinase that regulates cellular proliferation, migration, and differentiation during development. Increased expression of MET has been shown to correlate with poor prognosis in non-small cell carcinomas of the lung and tumors of other sites. Immunohistochemistry evaluation using the MET (SP44) antibody can aid in identifying non-squamous non-small cell lung cancer patients who may be eligible for MET targeted therapies.

Reference Values

An interpretive report will be provided.

Day(s) Performed

Monday through Friday

Report Available

5 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

88360