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Test Code MESOP Mesothelioma Panel (WT1/KRT5/TTF1/pCEA) Immunostain, Technical Component Only


Ordering Guidance


This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.



Shipping Instructions


Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Specimen Type: Tissue

Supplies: Immunostain Technical Only Envelope (T693)

Container/Tube: Immunostain Technical Only Envelope

Preferred:

-Formalin-fixed, paraffin-embedded tissue block

OR

-2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick

Acceptable: None


Useful For

Differentiation of mesothelioma and  non-small cell lung cancer

Method Name

Immunohistochemistry (IHC)

Reporting Name

WT1/KRT5/TTF1/pCEA IHC, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)
  Refrigerated 

Reject Due To

Wet/frozen tissue 
Cytology smears 
Nonformalin fixed tissue 
Nonparaffin embedded tissue 
Noncharged slides 
ProbeOn slides 
Snowcoat slides 		 Reject 

Clinical Information

The Mesothelioma Panel assay consists of 4 antibodies WT-1, KRT5, TTF1 (clone SPT24) and P-CEA. This multiplex immunohistochemistry assay is used in the differential diagnosis of mesothelioma and non-small cell lung cancer (NSCLC). WT-1 (nuclear; detected with green chromogen) and KRT5 (cytoplasmic; detected with purple chromogen) are biomarkers expressed in mesothelioma. TTF1 (nuclear; detected with red chromogen) and P-CEA (membranous/cytoplasmic; detected with teal chromogen) are biomarkers expressed in NSCLC.

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88344-TC

Forms

If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.