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Test Code IMPLF Immature Platelet Fraction, Blood


Specimen Required


Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL

Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.


Useful For

Assessing thrombopoietic activity with increased values observed when bone marrow is stimulated to produce platelets

 

Differentiating causes of thrombocytopenia

 

Predicting platelet recovery in patients undergoing treatments that affect platelet counts, such as chemotherapy

Method Name

Flow Cytometry

Reporting Name

Immature Platelet Fraction, B

Specimen Type

Whole Blood EDTA

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Whole Blood EDTA Refrigerated (preferred) 48 hours
  Ambient  24 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK
Clotted Reject

Clinical Information

Immature platelets or reticulated platelets are newly released thrombocytes. They can be identified by their large size and high RNA concentration in their cytoplasm. Immature platelet fraction (IPF) represents the number of immature platelets compared to the total number of platelets as a percentage.(1)

 

Immature platelet fraction is a direct cellular measurement of thrombopoiesis. It can be used to differentiate causes of thrombocytopenia. IPF can be low or normal in the setting of decreased platelet production (hypoproductive) and increased in the setting of platelet destruction (hyperdestructive/consumptive).(1)

 

Immature platelet fraction increases prior to platelet recovery after chemotherapy and after stem cell transplantation by 2 to 3 days. This can prevent unnecessary platelet transfusion and provide an indicator for a successful engraftment after both autologous and allogeneic stem cell transplantation.(2)

Reference Values

1.1-8.6%

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 day

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

85055