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HelpTest Code FAS1A Anti-SAE1 Ab, IgG
Specimen Required
Collection Container/Tube: 5 mL Red
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Acceptable: SST
Collection Instructions: Draw blood in a plain red-top tube(s), serum gel tube is acceptable. Spin down and send 1 mL of serum refrigerated in a plastic vial.
Method Name
Enzyme-linked immunosorbent assay (ELISA)
Reporting Name
Anti-SAE1 Ab, IgGSpecimen Type
SerumSpecimen Minimum Volume
0.5 mL (volume does NOT allow for repeat testing)
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 60 days | ||
| Ambient | 7 days |
Reject Due To
| Gross hemolysis: | Reject |
| Thawing: | Warm OK; Cold OK |
| Gross lipemia: | Reject |
| Gross icterus | Reject |
| Other: | Anything other than serum; bacterial contamination |
Clinical Information
Anti-SAE 1 IgG autoantibody can be used to assist in the diagnoses and characterization of a subset of dermatomyositis (DM). It is highly specific for DM (>95%) and is present in 5-8% of the European DM population.
Initial disease onset may consist of mild myopathic features with severe skin involvement; however, extensive myalgia and muscle disease with weakness can appear as the disease progresses. It is associated with dysphagia and systemic symptoms (i.e. fevers, weight loss, increased inflammatory markers). In one cohort, an association with ILD and cancer had been found.
Reference Values
Reference Range: <20
Interpretation:
Negative: <20 units
Weak Positive: 20-39 units
Moderate Positive: 40-80 units
Strong Positive: >80 units
Performing Laboratory
Esoterix EndocrinologyTest Classification
This test was developed and its characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.CPT Code Information
83516
Day(s) Performed
Monday through Friday