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Test Code FANG1 Angiotensin I, Plasma


Specimen Required


Patient preparation: Patient should be on a normal sodium diet, 110 mEq of sodium. Patient should be in a recumbent posture for at least 30 minutes prior to collection of specimen. Diuretics, mineralocorticoids, glucocorticoids, estrogens, oral contraceptives, and ACTH medications and sodium, potassium, and posture all affect Angiotensin levels.

Specimen Type: Plasma

Collection Container/Tube: EDTA

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions:

1. Draw blood in a lavender-top (EDTA) tube(s)

2. Centrifuge and aliquot 3 mL of plasma into a plastic vial.

3. Send frozen.


Method Name

Direct ELISA

Reporting Name

Angiotensin I, P

Specimen Type

Plasma EDTA

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma EDTA Frozen 30 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Clinical Information

Angiotensin I is a ten amino acid peptide formed by Renin cleavage of Angiotensinogen (Renin Substrate) I. Angiotensin I has little biological activity except that high levels cand stimulate Catecholamine production. It is metabolized to its biologically active byproduct Angiotensin II by Angiotensin Converting Enzyme (ACE). The formation of Angiotensin I is controlled by negative feedback of Angiotensin II and III on Renin release and by Aldosterone concentration. Levels of Angiotensin I are increased in many types of hypertension. Angiotensin I levels are used to determine Renin activity. Angiotensin I is excreted directly in the urine.

Reference Values

Up to 25 pg/mL

Day(s) Performed

Monday through Friday

Report Available

12 to 14 days

Performing Laboratory

Inter Science Institute

Test Classification

This test was developed and its performance characteristics determined by Inter Science Institute. Values obtained with different methods, laboratories, or kits cannot be used interchangeably with the results on this report. The results cannot be interpreted as absolute evidence of the presence or absence of malignant disease.

CPT Code Information

83520