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HelpTest Code CRPCR Carbapenem Resistance Genes, Molecular Detection, PCR, Rectal Swab
Ordering Guidance
This test is performed on rectal and perirectal swab specimens from patients at risk for intestinal colonization with bacteria not susceptible to carbapenem antimicrobials.
Other mechanisms of carbapenem resistance, including carbapenemases not targeted by this assay, porin mutations, and hyperexpression of drug efflux pumps, may result in carbapenem resistance. These mechanisms are not detected by this assay.
Specimen Required
Specimen Type: Rectal/perirectal swab
Supplies: Culturette (BBL Culture Swab) (T092)
Container/Tube: Culture transport swab
Specimen Volume: Entire collection
Useful For
Detecting and differentiating the blaKPC, blaNDM, blaVIM, blaOXA-48, and blaIMP gene sequences associated with carbapenem intermediate or resistant results
Aiding in infection control in the detection of gastrointestinal colonization of patients in healthcare settings with bacteria not susceptible to carbapenems using rectal or perirectal swabs
Method Name
Real-Time Polymerase Chain Reaction (RT-PCR)
Reporting Name
Carbapenem Resistance Genes, PCRSpecimen Type
SwabSpecimen Minimum Volume
See Specimen Required
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Swab | Ambient | 5 days |
Reject Due To
| Gross lipemia | Reject |
| Incorrect swab used | Reject |
Clinical Information
The global spread of carbapenemase-producing Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter species (organisms not susceptible to carbapenem antimicrobials) is a critical public health issue. These bacteria are often resistant to all beta-lactam agents and, frequently, are also resistant to multiple classes of other antimicrobial agents leaving very few treatment options. Tracing the spread of organisms not susceptible to carbapenems is complicated by the diversity of carbapenem-hydrolyzing enzymes that have emerged and the ability of the genes to spread among multiple bacterial species.
Reference Values
Not detected
Day(s) Performed
Monday through Sunday
Report Available
Same day/1 dayPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
87798
Forms
If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.