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HelpTest Code ALKLC Anaplastic Lymphoma Kinase for Lung Cancer, Immunohistochemistry
Shipping Instructions
Attach the green "Attention Pathology" address label (T498) to the outside of the transport container before putting into the courier mailer.
Necessary Information
A pathology/diagnostic report and a brief history, including primary site of neoplasm, are required.
Specimen Required
Specimen Type: Tissue
Supplies: Pathology Packaging Kit (T554)
Submit:
Formalin-fixed, paraffin-embedded tissue block
OR
3 Unstained glass, "positively charged" slides with 4-microns formalin-fixed, paraffin-embedded tissue
Additional Information: One slide will be stained with hematoxylin and eosin and returned.
Useful For
Identification of anaplastic lymphoma kinase (ALK) expression
Prediction of tumor response to targeted therapy of non-small cell lung carcinomas.
Method Name
Immunohistochemistry (IHC)
Reporting Name
ALK for Lung Cancer IHCSpecimen Type
SpecialSpecimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Special | Ambient (preferred) | |
| Refrigerated | ||
Reject Due To
| Wet/frozen tissue | Reject |
| Decalcified paraffin embedded tissue | Reject |
| Cytology smears | Reject |
| Nonformalin fixed tissue including alcohol-formalin-acetic acid (AFA), 95% ethanol, PREFER fixatives or zinc formalin | Reject |
| Nonparaffin embedded tissue | Reject |
| Noncharged slides | Reject |
| ProbeOn slides | Reject |
| Snowcoat slides | Reject |
Clinical Information
A subset of lung cancers, specifically adenocarcinomas, harbor anaplastic lymphoma kinase (ALK) rearrangements. Expression of ALK in tumor cells can be used as a surrogate marker for ALK rearrangement. The presence of ALK rearrangement (ALK protein expression) is a predictive biomarker for response to ALK tyrosine kinase inhibitors.
Day(s) Performed
Monday through Friday
Report Available
5 to 7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
88342-Primary
88341-If additional IHC
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IHPCA | IHC Additional | No | No |
| IHPCI | IHC Initial | No | No |
Forms
If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.