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Test Code SSX18 Synovial Sarcoma Panel, Technical Component Only


Ordering Guidance


This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required, order PATHC / Pathology Consultation.



Shipping Instructions


Attach the green "Attention Pathology" address label (T498) and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Specimen Type: Tissue

Supplies: Immunostain Technical Only Envelope (T693)

Container/Tube: Immunostain Technical Only Envelope

Preferred:

-Formalin-fixed, paraffin-embedded tissue block

OR

-2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick

Acceptable: None


Useful For

Aiding in distinguishing synovial sarcomas from similar sarcomas

Method Name

Immunohistochemistry (IHC)

Reporting Name

Synovial sarcoma panel IHC, T Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time Special Container
TECHONLY Ambient (preferred)
  Refrigerated 

Reject Due To

Wet/frozen tissue
Cytology smears
Nonformalin fixed tissue
Nonparaffin embedded tissue
Noncharged slides
ProbeOn slides
Snowcoat slides		 Reject 

Clinical Information

The SS18-SSX fusion-specific antibody and SSX C-terminal antibody are markers used for the diagnosis of synovial sarcoma.

 

The SS18-SSX fusion-specific antibody recognizes SS18-SSX fusion proteins, which are a result of the SS18 gene fusing with SSX gene on chromosome 18. This translocation is unique to synovial sarcoma. SSX C-terminal antibody recognizes endogenous levels of SSX (1-4) proteins and the SS18-SSX fusion protein. Using these two antibodies together will aid in distinguishing synovial sarcomas from other histologically similar sarcomas.

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

88342-TC, primary

88341-TC, if additional IHC

Forms

If not ordering electronically, complete, print, and send a Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.