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Test Code SABP Streptococcal Antibodies Profile, Serum

Reporting Name

Streptococcal Antibodies Profile

Useful For

Demonstration of acute or recent streptococcal infection using both antistreptolysin O and anti-DNase B titers

Profile Information

Test ID Reporting Name Available Separately Always Performed
ASO Antistrep-O Titer, S Yes Yes
ADNAS Anti-DNase B Titer, S Yes Yes

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Patient Preparation: Fasting preferred but not required

Collection Container/Tube: 

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  7 days

Reference Values

ANTISTREP-O TITER

<5 years: ≤70 IU/mL

5-17 years: ≤640 IU/mL

≥18 years: ≤530 IU/mL

 

ANTI-DNase B TITER

<5 years: ≤250 U/mL

5-17 years: ≤375 U/mL

≥18 years: ≤300 U/mL

Day(s) Performed

Monday through Friday

CPT Code Information

86060

86215

Clinical Information

A number of bacterial antigens have been identified in cultures of group A streptococci. These extracellular products are primarily enzymatic proteins and include streptolysin O, streptokinase, hyaluronidase, deoxyribonucleases (DNases A, B, C, and D), and nicotinamide adenine nucleotidase.

 

Infections by the group A streptococci are unique because they can be followed by the serious nonpurulent complications of rheumatic fever and glomerulonephritis. Recent information suggests that rheumatic fever is associated with infection by certain rheumatogenic serotypes (M1, M3, M5, M6, M18, and M19), while glomerulonephritis follows infection by nephritogenic serotypes (M2, M12, M49, M57, M59, and M60).

 

Glomerulonephritis and rheumatic fever occur following the infection, after a period of latency following the infection, during which the patient is asymptomatic. The latency period for glomerulonephritis is approximately 10 days, and for rheumatic fever the latency period is 20 days.

Report Available

1 to 3 days

Reject Due To

Gross hemolysis OK
Gross lipemia Reject
Gross icterus OK

Method Name

Nephelometry

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.