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Test Code OXCO1 Oxalate, Random, Urine


Specimen Required


Only orderable as part of a profile. For more information see ROXUR / Oxalate, Random, Urine.

 

Patient Preparation: Avoid taking large doses (>2 g orally/24 hours) of vitamin C prior to specimen collection.

Supplies: Urine Tubes, 10 mL tube (T068)

Container/Tube: 10-mL plastic tube or a clean, plastic container with no metal cap

Specimen Volume: 7 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

3. Specimen pH should be between 4.5 and 8 and will stay in this range if kept refrigerated. Specimens with pH above 8 may indicate bacterial contamination, and testing will be cancelled. Do not attempt to adjust pH as it will adversely affect results.

Useful For

Monitoring therapy for kidney stones

 

Identifying increased urinary oxalate as a risk factor for stone formation

 

Diagnosis of primary or secondary hyperoxaluria

Method Name

Only orderable as part of a profile. For more information see ROXUR / Oxalate, Random, Urine.

 

Enzymatic Using Oxalate Oxidase

Reporting Name

Oxalate, Random, U (mmol/L)

Specimen Type

Urine

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  72 hours

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Clinical Information

Oxalate is an end product of glyoxalate and glycerate metabolism. Humans have no enzyme capable of degrading oxalate so it must be eliminated by the kidney.

 

In tubular fluid, oxalate can combine with calcium to form calcium oxalate stones. In addition, high concentrations of oxalate may be toxic for renal cells.

 

Increased urinary oxalate excretion results from inherited enzyme deficiencies (primary hyperoxaluria), gastrointestinal disorders associated with fat malabsorption (secondary hyperoxaluria), or increased oral intake of oxalate-rich foods or vitamin C.

 

Since increased urinary oxalate excretion promotes calcium oxalate stone formation, various strategies are employed to lower oxalate excretion.

Reference Values

Only orderable as part of a profile. For more information see ROXUR / Oxalate, Random, Urine.

 

No established reference values

Day(s) Performed

Monday through Saturday

Report Available

3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83945