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HelpTest Code MSFNG Fibronectin Glomerulopathy Confirmation, Mass Spectrometry
Necessary Information
Preliminary pathology report, history, and electron microscopy images are required.
Specimen Required
Supplies: Pathology Packaging Kit (T554)
Specimen Type: Formalin-fixed, paraffin-embedded kidney tissue block
Collection Instructions: Do not send fixed tissue slides. Testing can only be done on paraffin-embedded tissue blocks.
Useful For
Aiding in the diagnosis of fibronectin glomerulopathy
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| MLCPC | Microdissection, Laser Capture | No, (Bill Only) | No |
| MSPTC | Mass Spectrometry | No, (Bill Only) | No |
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
FNG Confirm, LC MSSpecimen Type
SpecialSpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Special | Ambient (preferred) | ||
| Frozen | |||
| Refrigerated | |||
Reject Due To
| Fixed tissue slides Wet/frozen tissue Cytological smears Nonformalin fixed tissue Nonparaffin embedded tissue |
Reject |
Clinical Information
Fibronectin glomerulopathy, also called glomerulopathy with fibronectin deposits 2 (GFND2), is a rare kidney disease characterized by large amounts of fibronectin deposits in the mesangium and subendothelial space of renal glomeruli. Liquid chromatography tandem mass spectrometry performed on microdissected glomeruli from patients with GFND2 demonstrates a unique proteomic profile. The presence of abnormal fibronectin deposits, in the appropriate clinical and pathological context, can be useful to establish a diagnosis of GFND2.
Day(s) Performed
Monday through Friday
Report Available
7 to 15 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82542
88380
Forms
If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.