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HelpTest Code CXCR3 C-X-C Motif Chemokine Receptor 3 (CXCR3), Technical Component Only
Ordering Guidance
Technical component only stains should not be ordered with PATHC / Pathology Consultation. If ordered with PATHC, the technical component stains will be canceled. Any immunohistochemistry (IHC)/in situ hybridization (ISH) stain performed as a part of the PATHC will be performed at the reviewing pathologist's discretion at an additional charge.
Shipping Instructions
Attach the green "Attention Pathology" address label (T498) and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.
Specimen Required
Specimen Type: Tissue
Supplies: Immunostain Technical Only Envelope (T693)
Container/Tube: Immunostain Technical Only Envelope
Submit
Formalin-fixed, paraffin-embedded tissue block
OR
2 Unstained, positively charged glass slides (25- x 75- x 1-mm) per test ordered; sections 4-microns thick
Useful For
Classification of T-cell lymphomas
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IHTOI | IHC Initial, Tech Only | No | No |
| IHTOA | IHC Additional, Tech Only | No | No |
Method Name
Immunohistochemistry (IHC)
Reporting Name
CXCR3 IHC, Tech OnlySpecimen Type
TECHONLYSpecimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| TECHONLY | Ambient (preferred) | |
| Refrigerated | ||
Reject Due To
| Wet/frozen tissue | Reject |
| Cytology smears | Reject |
| Nonformalin fixed tissue | Reject |
| Nonparaffin embedded tissue | Reject |
| Noncharged slides | Reject |
| ProbeOn slides | Reject |
| Snowcoat slides | Reject |
Clinical Information
About 30% to 50% of peripheral T-cell lymphomas (PTCLs) do not meet diagnostic criteria for an established subtype (not otherwise specified, NOS). Among these PTCL-NOS cases, two molecular subtypes identified by gene expression profiling have been designated as PTCL-GATA3 and PTCL-TBX21. Both molecular subtypes are associated with poor clinical outcomes with PTCL-GATA3 having significantly worse overall survival. An immunohistochemistry algorithm assessing TBX21 (T-bet), CXCR3 (C-X-C chemokine receptor type 3), GATA3 (GATA binding protein 3), and CCR4 (C-C motif chemokine receptor 4) exhibits high sensitivity and reproducibility to further classify PTCL-NOS.
Day(s) Performed
Monday through Friday
Report Available
1 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
88342-TC, Primary
88341-TC, If additional IHC