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HelpTest Code CENO Cenobamate, Serum
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1.2 mL Serum
Collection Instructions: Within 2 hours of collection, centrifuge, and aliquot serum into a plastic vial.
Useful For
Monitoring serum concentrations of cenobamate to optimize efficacy and minimize toxicity
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Cenobamate, SSpecimen Type
Serum RedSpecimen Minimum Volume
Serum: 0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days |
| Ambient | 28 days | |
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Clinical Information
Cenobamate was approved by the US Food and Drug Administration for the treatment of partial-onset seizures in adult patients. Cenobamate reduces repetitive neuronal firing by inhibiting voltage-gated sodium currents and is a positive allosteric modulator of the gamma-aminobutyric acid (GABA-A) ion channel.
Common side effects may include double vision (diplopia), dizziness, somnolence, fatigue, or headache. Severe effects include QT interval shortening and acute hepatic failure.
Cenobamate has good oral bioavailability (88%) is extensively metabolized and primarily eliminated through the renal system (approximately 6% unchanged) with a long elimination half-life (50-60 hours).
Reference Values
Trough concentrations of 5 to 35 mcg/mL for daily dosages of 100 to 400 mg/day
Day(s) Performed
Monday through Friday
Report Available
Same day/1 to 2 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80299