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HelpTest Code BTR Isoagglutinin Titer, Anti-B, Serum
Shipping Instructions
Specimen must arrive within 10 days of collection.
Specimen Required
Supplies: Sarstedt 5 mL Aliquot Tube (T914)
Collection Container/Tube: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 2.5 mL
Pediatric Volume: 2 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial.
Useful For
Evaluation of individuals with possible hypogammaglobulinemia
Method Name
Hemagglutination
Reporting Name
Isoagglutinin Titer, Anti-BSpecimen Type
Serum RedSpecimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Ambient (preferred) | 4 days | |
| Frozen | 10 days | ||
| Refrigerated | 10 days |
Reject Due To
| Gross hemolysis | OK |
Clinical Information
Isoagglutinins are antibodies produced by an individual that cause agglutination of red blood cells (RBC) in other individuals. People possess isoagglutinins directed toward the A or B antigen absent from their own RBC. For example, type A or O individuals will usually possess anti-B. The anti-B is formed in response to exposure to B-like antigenic structures found in ubiquitous non-red blood cell biologic entities (eg, bacteria).
Isoagglutinins present in the newborn are passively acquired from maternal circulation. Such passively acquired isoagglutinins will gradually disappear, and the infant will begin to produce isoagglutinins at 3 to 6 months of age.
Isoagglutinin production may vary in patients with certain pathologic conditions. Decreased levels of isoagglutinins may be seen in patients with acquired and congenital hypogammaglobulinemia and agammaglobulinemia.
Reference Values
Interpretation depends on clinical setting. No defined reference values.
Day(s) Performed
Monday through Friday, Sunday
Report Available
1 to 4 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86886
Forms
If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen.