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Test Code ALUPI Lupus Anticoagulant Profile, Technical Interpretation


Specimen Required


Only orderable as part of a profile. For more information see ALUPP / Lupus Anticoagulant Profile, Plasma.


Useful For

Technical interpretation of testing to confirm or exclude the presence of lupus anticoagulant (LAC)

 

Distinguishing LAC from specific coagulation factor inhibitors and nonspecific inhibitors

 

Investigating a prolonged activated thromboplastin time, especially when combined with other coagulation studies

 

This test is not useful for the detection of antiphospholipid antibodies that do not affect coagulation tests. We recommend separate testing for serum phospholipid (cardiolipin) antibodies.

Method Name

Only orderable as part of a profile. For more information see ALUPP / Lupus Anticoagulant Profile, Plasma.

 

Technical Interpretation

Reporting Name

Lupus Anticoagulant Tech Interp

Specimen Type

Plasma Na Cit

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Clinical Information

Lupus anticoagulant (LAC) is an antibody to negatively charged phospholipid that interferes with phospholipid-dependent coagulation tests.

 

LAC is found in, but not limited to, patients with systemic lupus erythematosus; LAC is associated with other autoimmune disorders and collagen vascular disease, occurs in response to medications or certain infections (eg, respiratory tract infections in children), and in individuals with no obvious underlying disease.

 

LAC has been associated with arterial and venous thrombosis and fetal loss. Individuals with thrombocytopenia or factor II deficiency associated with LAC may be at risk for bleeding.

Reference Values

Only orderable as part of a profile. For more information see ALUPP / Lupus Anticoagulant Profile, Plasma.

 

An interpretive report will be provided.

Day(s) Performed

Monday through Friday

Report Available

3 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

Not Applicable

CPT Code Information

85390