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Test Code AAGTS Alpha-3 Beta-4 Ganglionic Neuronal Acetylcholine Receptor Binding Antibody, Flow Cytometry Titer, Serum (Non-Orderable)


Specimen Required


Only orderable as a reflex. For more information see:

-DYS2 / Dysautonomia, Autoimmune/Paraneoplastic Evaluation, Serum

-GID2 / Gastrointestinal Dysmotility, Autoimmune/Paraneoplastic Evaluation, Serum


Useful For

Only orderable as a reflex. For more information see:

DYS2 / Dysautonomia, Autoimmune/Paraneoplastic Evaluation, Serum

GID2 / Gastrointestinal Dysmotility, Autoimmune/Paraneoplastic Evaluation, Serum

 

Evaluating patients with suspected autoimmune autonomic ganglionopathy and autoimmune gastrointestinal dysmotility using serum specimens

 

Reporting alpha-3 beta-4 ganglionic neuronal acetylcholine receptor binding antibody end titer results of as part of a profile

Method Name

Only orderable as a reflex. For more information see:

-DYS2 / Dysautonomia, Autoimmune/Paraneoplastic Evaluation, Serum

-GID2 / Gastrointestinal Dysmotility, Autoimmune/Paraneoplastic Evaluation, Serum

 

Flow Cytometry

Reporting Name

AChR Alpha3 Gang Flow Titer, S

Specimen Type

Serum

Specimen Minimum Volume

Serum: 1 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Clinical Information

The assay for ganglionic acetylcholine receptor binding antibodies (alpha-3 beta-4) is most useful as a screening test for autoimmune autonomic ganglionopathy (AAG), a form of autoimmune dysautonomia which can manifest as pandysautonomia (several of fixed pupillary dilatation, orthostatic hypotension, sweat loss, gastroparesis, small bowel pseudo-obstruction, constipation and urinary retention due to bladder hypocontractility) or limited forms such as autoimmune gastrointestinal dysmotility. Occasionally, AAG may occur in a paraneoplastic context accompanying diverse carcinomas or thymoma. AAG is generally an immune therapy responsive disease.

Reference Values

Only orderable as a reflex. For more information see:

-DYS2 / Dysautonomia, Autoimmune/Paraneoplastic Evaluation, Serum

-GID2 / Gastrointestinal Dysmotility, Autoimmune/Paraneoplastic Evaluation, Serum

 

<1:10

Day(s) Performed

Varies

Report Available

3 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86256