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HelpTest Code SSH24 Supersaturation Profile, Self-Collect, 24 Hour, Urine
Ordering Guidance
Necessary Information
1. 24-Hour volume in milliliters is required.
2. Patient's height in centimeters and weight in kilograms are required if patient is younger than 18 years.
3. Patient's street address, city, state, ZIP (postal) code, country, and home phone are required (post-office [PO] boxes are not acceptable delivery locations)
Specimen Required
Patient Preparation:
X-ray dyes and contrast media will affect uric acid test results.
-If a kidney X-ray with dye or computerized tomography (CT) scan with contrast has been performed, the patient should wait at least 24 hours before starting collection.
-If a cholangiography (bile duct X-ray) has been performed, the patient should wait 7 days before starting collection.
-If patient has taken tablets for a gallbladder X-ray, the patient should wait 7 days before starting collection.
Supplies: SSH24 Home Collection Kit (T921)
Collection Container/Tube: 24-hour graduated urine container with no metal cap or glued insert
Submission Container/Tube: Plastic, 60-mL urine bottle
Specimen Volume: 35 mL
Collection Instructions:
1. Order test each time the patient is to collect a 24-hour urine specimen at home and mail the specimen directly to Mayo Clinic Laboratories.
2. Order should be placed a minimum of 3 days prior to desired date of collection.
3. Enter patient's address information for each order created, including street address (post office [PO] boxes are not acceptable delivery locations), city, state abbreviation, zip code, country, and home phone number.
4. For each order, the SSH24 Home Collection kit will be mailed directly to the patient for self-collection (delivery to a PO box will not occur). This kit contains instructions for how to properly collect and transport the specimen after collection.
Useful For
Diagnosis and management of patients with renal lithiasis:
-Predicting the likely composition of the stone, in patients who have a radiopaque stone, for whom stone analysis is not available
-May aid in designing a treatment program
Aiding in identification of specific risk factors for stones using a 24-hour urine collection
Monitoring the effectiveness of therapy by confirming that the crystallization potential has indeed decreased
Evaluating kidney excretion of acid and urine pH
Estimating a patient's protein intake
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SSIN1 | Supersaturation, 24 HR,Home Kit,U 1 | No | Yes |
| NAUT | Sodium, 24 HR, U | Yes, (order NAU) | Yes |
| KUT | Potassium, 24 HR, U | Yes, (order KUR) | Yes |
| CALUT | Calcium, 24 HR, U | Yes, (order CALU) | Yes |
| MAGT | Magnesium, 24 HR, U | Yes, (order MAGU) | Yes |
| CLUT | Chloride, 24 HR, U | Yes, (order CLU) | Yes |
| POUT | Phosphorus, 24 HR, U | Yes, (order POU) | Yes |
| SULFT | Sulfate, 24 HR, U | Yes, (order SULFU) | Yes |
| CITT | Citrate Excretion, 24 HR, U | Yes, (order CITR) | Yes |
| OXUT | Oxalate, 24 HR, U | Yes, (order OXU) | Yes |
| UPHT | pH, 24 HR, U | Yes, (order PHU_) | Yes |
| URICT | Uric Acid, 24 HR, U | Yes, (order URCU) | Yes |
| CTUT | Creatinine, 24 HR, U | Yes, (order CTU) | Yes |
| OSMUT | Osmolality, 24 HR, U | Yes, (order UOSMU) | Yes |
| AMMT | Ammonium, 24 HR, U | Yes, (order AMMO) | Yes |
| UNT | Urea Nitrogen, 24 HR, U | No | Yes |
| PCRUT | Protein Catabolic Rate, 24 HR, U | No | Yes |
| DEMO9 | Patient Demographics | No | Yes |
Method Name
AMMT, CITT, OXUT: Enzymatic
OSMUT: Freezing Point Depression
SULFT: High-Performance Ion Chromatography (HPIC)
CALUT, POUT: Photometric
MAGT: Colorimetric Endpoint Assay
UPHT: pH Meter
NAUT, KUT, CLUT: Potentiometric, Indirect Ion-Selective Electrode (ISE)
CTUT: Enzymatic Colorimetric Assay
URICT: Uricase
UNT: Kinetic UV Assay
Reporting Name
Supersaturation, 24 HR, Home Kit, USpecimen Type
UrineSpecimen Minimum Volume
25 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days | ||
| Ambient | 72 hours |
Reject Due To
| pH <4.5 or pH >8.0 | Reject |
Clinical Information
Urine is often supersaturated, which favors precipitation of several crystalline phases, such as calcium oxalate, calcium phosphate, and uric acid. However, crystals do not always form in supersaturated urine because supersaturation is balanced by crystallization inhibitors that are present in the urine. Urinary inhibitors include ions (eg, citrate) and macromolecules but remain poorly understood.
Urine supersaturation is calculated by measuring the concentration of all the ions that can interact (potassium, calcium, phosphorus, oxalate, uric acid, citrate, magnesium, sodium, chloride, sulfate, and pH). Once the concentrations of all the relevant urinary ions are known, a computer program can calculate the theoretical supersaturation with respect to the important crystalline phases (eg, calcium oxalate).(1)
Since the supersaturation of urine has been shown to correlate with stone type,(2) therapy is often targeted towards decreasing the urinary supersaturations identified. Treatment strategies include alterations in diet and fluid intake as well as drug therapy; all designed to decrease the urine supersaturation.
Reference Values
SUPERSATURATION REFERENCE MEANS (Delta G: DG)
Men:
Calcium oxalate: 1.89 DG
Brushite: 0.46 DG
Hydroxyapatite: 4.19 DG
Uric acid: 1.18 DG
Women:
Calcium oxalate: 1.59 DG
Brushite: -0.11 DG
Hydroxyapatite: 3.62 DG
Uric acid: 0.89 DG
OSMOLALITY, 24 HOUR, URINE
0-11 months: 50-750 mOsm/kg
≥12 months: 150-1,150 mOsm/kg
pH, 24 HR, U
4.5-8.0
SODIUM, 24 HOUR, URINE
≥18 years: 22-328 mmol/24 h
Reference values have not been established for patients who are younger than 18 years.
POTASSIUM. 24 HOUR, URINE
≥18 years: 16-105 mmol/24 h
Reference values have not been established for patients who are younger than 18 years.
CALCIUM, 24 HOUR, URINE
Males: <250 mg/24 h
Females: <200 mg/24 h
Reference values have not been established for patients who are younger than 18 years.
MAGNESIUM, 24 HOUR URINE
≥18 years: 51-269 mg/24 h
Reference values have not been established for patients who are younger than 18 years.
CHLORIDE, 24 HOUR URINE
≥18 years: 34-286 mmol/24 h
Reference values have not been established for patients who are younger than 18 years.
PHOSPHORUS, 24 HOUR, URINE
≥18 years: 226-1,797 mg/24 h
Reference values have not been established for patients who are younger than 18 years of.
SULFATE, 24 HOUR, URINE
7-47 mmol/24 h
CITRATE EXCRETION, 24 HOUR, URINE
0-19 years: Not established
20 years: 150-1,191 mg/24 h
21 years: 157-1,191 mg/24 h
22 years: 164-1,191 mg/24 h
23 years: 171-1,191 mg/24 h
24 years: 178-1,191 mg/24 h
25 years: 186-1,191 mg/24 h
26 years: 193-1,191 mg/24 h
27 years: 200-1,191 mg/24 h
28 years: 207-1,191 mg/24 h
29 years: 214-1,191 mg/24 h
30 years: 221-1,191 mg/24 h
31 years: 228-1,191 mg/24 h
32 years: 235-1,191 mg/24 h
33 years: 242-1,191 mg/24 h
34 years: 250-1,191 mg/24 h
35 years: 257-1,191 mg/24 h
36 years: 264-1,191 mg/24 h
37 years: 271-1,191 mg/24 h
38 years: 278-1,191 mg/24 h
39 years: 285-1,191 mg/24 h
40 years: 292-1,191 mg/24 h
41 years: 299-1,191 mg/24 h
42 years: 306-1,191 mg/24 h
43 years: 314-1,191 mg/24 h
44 years: 321-1,191 mg/24 h
45 years: 328-1,191 mg/24 h
46 years: 335-1,191 mg/24 h
47 years: 342-1,191 mg/24 h
48 years: 349-1,191 mg/24 h
49 years: 356-1,191 mg/24 h
50 years: 363-1,191 mg/24 h
51 years: 370-1,191 mg/24 h
52 years: 378-1,191 mg/24 h
53 years: 385-1,191 mg/24 h
54 years: 392-1,191 mg/24 h
55 years: 399-1,191 mg/24 h
56 years: 406-1,191 mg/24 h
57 years: 413-1,191 mg/24 h
58 years: 420-1,191 mg/24 h
59 years: 427-1,191 mg/24 h
60 years: 434-1,191 mg/24 h
>60 years: Not established
OXALATE, 24 HOUR, URINE
0.11-0.46 mmol/24 h
9.7-40.5 mg/24 h
URIC ACID, 24 HOUR, URINE
Male: ≥18 years: 200-1,000 mg/24 h
Female: ≥18 years: 250-750 mg/24 h
Reference values have not been established for patients who are younger than 18 years.
CREATININE, 24 HOUR, URINE
Male: ≥18 years: 930-2,955 mg/24 h
Female: ≥18 years: 603-1,783 mg/24 h
Reference values have not been established for patients who are younger than 18 years.
AMMONIUM, 24 HOUR, URINE
15-56 mmol/24 h
Reference values have not been established for patients who are younger than18 years or older than 77 years.
UREA NITROGEN, 24 HOUR, URINE
≥18 years: 7-42 g/24 h
Reference values have not been established for patients who are younger than 18 years.
PROTEIN CATABOLIC RATE, 24 HOUR, URINE
56-125 g/24 h
Day(s) Performed
Monday through Sunday
Report Available
2 to 5 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82340-Calcium
82436-Chloride
82507-Citrate excretion
82570-Creatinine
83735-Magnesium
83935-Osmolality
83945-Oxalate
83986-pH
84105-Phosphorus
84133-Potassium
84300-Sodium
84392-Sulfate
84560-Uric acid
82140-Ammonium
84540-Urea Nitrogen