Sign in →

Test Code MAGE4 Melanoma-associated antigen-A4 (MAGE-A4), Semi-Quantitative Immunohistochemistry, Manual


Shipping Instructions


Attach the green "Attention Pathology" address label (T498) to the outside of the transport container before putting into the courier mailer.



Necessary Information


A pathology/diagnostic report and a brief history are required.



Specimen Required


Specimen Type: Tissue

Supplies: Pathology Packaging Kit (T554)

Submit:

Formalin-fixed, paraffin-embedded tissue block

OR

3 Unstained glass, positively charged slides with 4-microns formalin-fixed, paraffin-embedded tissue

Additional Information: One slide will be stained with hematoxylin and eosin and returned.


Useful For

Determining expression of melanoma-associated antigen-A4 (MAGE-A4) in synovial sarcoma and other neoplasms

 

As an aid in screening patients who may be eligible for TECELRA (afamitresgene autoleucel) therapy

Method Name

Immunohistochemistry (IHC)

Reporting Name

MAGE-A4, SemiQuant IHC, Manual

Specimen Type

Special

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time
Special Ambient (preferred)
  Refrigerated 

Reject Due To

Decalcified paraffin embedded tissue Reject
Wet/frozen tissue Reject
Cytology smears Reject
Nonformalin fixed tissue including alcohol-formalin-acetic acid (AFA), 95% ethanol, PREFER fixatives or Zinc formalin Reject
Nonparaffin embedded tissue Reject
Noncharged slides Reject
ProbeOn slides Reject
Snowcoat slides Reject

Clinical Information

Melanoma-associated antigen-A4 (MAGE-A4) is a cancer testis antigen (CTA). CTAs are targets for T-cell receptor immunotherapy. The MAGE-A4 immunohistochemical assay aids in identifying patients with synovial sarcoma and potentially other tumors for treatment with TECELRA (afamitresgene autoleucel), a MAGE-A4-directed genetically modified autologous T-cell immunotherapy.

Reference Values

An interpretive report will be provided.

Day(s) Performed

Monday through Friday

Report Available

5 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

88360