Home
HelpTest Code JCV JC Virus Detection by In Situ Hybridization
Shipping Instructions
Attach the green "Attention Pathology" address label (T498) and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.
Necessary Information
A pathology or diagnostic report (final or preliminary) and brief history are required and must accompany specimen for testing to be performed.
Specimen Required
Specimen Type: Tissue
Supplies: Pathology Packaging Kit (T554)
Submit:
Formalin-fixed, paraffin-embedded tissue block (preferred)
OR
4 Unstained glass, positively-charged slides with 5 (+ or -1)-micron formalin-fixed, paraffin-embedded tissue
Additional Information: Broken or cracked unstained slides will be rejected.
Useful For
Confirming a clinical and histopathologic diagnosis of progressive multifocal leukoencephalopathy
Method Name
In Situ Hybridization (ISH)
Reporting Name
JC Virus ISHSpecimen Type
SpecialSpecimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Special | Ambient (preferred) | |
| Refrigerated | ||
Reject Due To
| Wet/frozen tissue | Reject |
| Cytology smears | Reject |
| Non-formalin fixed tissue | Reject |
| Nonparaffin embedded tissue | Reject |
| Kidney/renal tissue | Reject |
| Noncharged, ProbeOn, and Snowcoat slides | Reject |
| Broken or cracked unstained slides | Reject |
Clinical Information
JC virus causes progressive multifocal leukoencephalopathy (PML), a rare, often fatal demyelinating disorder of the central nervous system that occurs in individuals with immune deficiency. PML is an infrequent complication of a wide variety of conditions, including lymphoproliferative disorders (Hodgkin disease and chronic lymphocytic leukemia), sarcoidosis, tuberculosis, and AIDS.
Day(s) Performed
Monday through Friday
Report Available
5 to 7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
88365-Primary
88364-If additional ISH
Forms
If not ordering electronically, complete, print, and send an Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.